Use Cases

Integrated Multiplex PCR System with Automated Sample Processing

• The invention is a fully automated, sample-to-result multiplex PCR (mPCR) system designed for detecting pathogens in faecal specimens. It eliminates the need for specialized equipment by integrating all necessary functions—sample pre-processing, DNA extraction, amplification, and fluorescence-based detection—into a compact, modular device.

• The system features a novel microfluidic Biochip that orchestrates fluid handling, centrifugation, ultrasonic lysis, and multi-channel optical detection. The Biochip’s sequential chambers enable cell lysis, nucleic acid binding, washing, and qPCR amplification, enhancing efficiency and accuracy. With modular mechanical, thermal, and optical subsystems, the device is optimized for high-throughput pathogen detection, making it suitable for diverse clinical settings.

Multi-spectral Scanning Microscope

The present invention provides a novel whole-slide multispectral scanning microscope system designed for multiplexed cell imaging. The system integrates:

• A multispectral imaging module capable of capturing high-resolution images at multiple wavelengths.

• An automated precision stage for accurate and rapid sample positioning.

• A high-speed auto-focusing mechanism ensuring consistent image clarity across the entire slide.

• Advanced image processing techniques for fusion, stitching, and pattern recognition.

• AI-assisted analysis to detect and classify tumor cells based on multispectral fluorescence patterns.

• This invention offers increased accuracy in pathology by enabling real-time detection and analysis of multiple biomarkers within a single tissue sample. The system is designed for high-throughput operation, ensuring rapid and reliable image acquisition and processing.

Development of Nonlinear Multi-spectral Imaging (NMSI) Platform

The invention provides a proprietary foldable and mobile NMSI platform capable of real-time, non-invasive, and high-resolution imaging for pathological and laparoscopic applications. The key innovations include:
 

• A flexible and compact nonlinear imaging laparoscope for minimally invasive procedures.

• A foldable mobile NMSI platform with a high degree of freedom (DOF) for accessibility.

• Advanced AI-assisted digital pathology imaging and analysis.

• Femtosecond laser pulse shaping for enhanced medical imaging efficiency.

• The system enables real-time visualization of tissue structures and biomarkers such as SHG, CARS, SRS, and TPEF signals for various cellular studies, improving diagnostic accuracy while eliminating the need for biopsies and staining.